Finasteride

Finasteride
(Toremifene citrate) Finasteride has been available for many years as Proscar (5mg tab), but only recently became available Propecia (1 mg). It is in a class of chemicals known as 5alpha-reductase inhibitors. It is based on the skeleton of progesterone (4) and has a strong inhibitory activity of the enzyme for the 5alpha-reductase (5-AR). 5-AR, as you recall, is the enzyme responsible for conversion of certain steroids in the 5-alpha-reduced version of themselves (such as the transformation of testosterone to dihydrotestosterone). Finasteride and compounds used for the treatment of androgen dependent diseases such as androgenic alopecia (hair loss), benign prostatic hyperplasia (increase of the prostate) and prostate cancer. Dihydrotestosterone is 5alpha reduced metabolites of testosterone and have been implicated as a causal factor in the development and progression of these problems. This was discovered when the men who are genetically deficiencies in the enzyme steroid 5alpha-reductase, showed a significant decrease of these problems (1) (2). Of course, these problems can be a great annoyance, and nothing about a toy, but to help you reduce your risk of finasteride on the achievements of the cycle in May and even suppress the reproductive function (3). I'm not a big fan, as you can guess. However, if you're worried about your hair, prostate or event in your family, then 1mg/day of finasteride May be the answer you are looking for. It should be noted that, in reality, it is 2 different enzyme 5-AR and finasteride to block the type II class. Type II-5-AR enzyme is primarily responsible for the increase in hairloss and prostate, as I type is often the cause of acne and hirsutism. In any case, the type-II meets approximately 2/3rds of the DGT in circulation in the body, it is not surprising that finasteride reduces the general level of DGT approximately 65%. There are also some new information about this compound on the conversion of testosterone to DGT through 5-alpha-reducatase enzyme. It is to my attention that the process of conversion of testosterone to the DGT in May of this enzyme to act in any way preclude the release of luteinizing hormone (and therefore hinder your HPTA and natural production of testosterone). Check it: In principle, this diagram shows the basic increase of LH in male sheep with a 5-alpha-reductase inhibitors (eg finasteride), followed by one showing LH, taking into account the sheep testosterone propionate, and a table showing the level of testosterone propionate given sheep LH + inhibitor (Figure 3). (5) Have you noticed that when using the inhibitor not only has no significant effects of LH, when administered with testosterone, it seems, LH pulsality authorized to continue almost unchanged. May This means you can use finasteride on a cycle (1mg/day), and possibly save your normal LH (and thus, your HPTA), Ergo easier recovery. This, of course, all my speculation. Information: 1. Steroidal antiandrogens and 5alpha-reductase inhibitors. Currency Med Chem. 2005, 12 (8) :927-43. 2. New 5alpha-reductase inhibitors: in vitro and in vivo effects. Steroids. 2005 Mar; 70 (3) :217-24. 3. [Effect of selective 5alpha-reductase inhibitor and / or testosterone undecanoate on the reproductive function of male rats] Zhonghua Nan Ke Xue. January 2005, 11 (1) :38-41. Chinese. 4. New aromatic esters of progesterone antiandrogens. J Med Khim enzyme inhib. April 2004, 19 (2) :99-105. 5. Biology of Reproduction 50, 1244-50 (1994)